Sildenafil and Metoprolol. Can You Take Them Together?

sildenafil and metoprolol together
, reviewed by​
Kim Matthews
 – Updated October 21, 2022
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You should not take Sildenafil and Metoprolol together without a doctor’s prescription and precise instructions.

There is no therapeutic duplication for these drugs (clear instructions on when and in what sequence you should use the drugs). However, their interaction may cause adverse side effects.

Sildenafil dilates blood vessels, which speeds up and facilitates blood movement through the arteries. Metoprolol has a hypotensive effect: blood pressure begins to decrease 15 minutes after taking the drug, with the effect reaching a maximum after 2 hours. The drug lasts six hours.

Sildenafil may enhance the hypotensive effect of Metoprolol. Simultaneous use of these drugs can cause a sudden decrease in blood pressure and lead to the following consequences:

  • Dizziness;
  • Presyncope and even fainting;
  • Hot flushes;
  • Headache;
  • Symptoms of tachycardia (which Metoprolol have to fight). You may have an increased pulse or heart rate.

According to doctors, you have a high chance of having these problems:

  • At the start of treatment;
  • After a dose increase;
  • When resuming the therapy after a long time.

You should consider it if you take Sildenafil and Metoprolol simultaneously.

There is also a prejudice that taking beta-blockers like Metoprolol leads to erectile dysfunction or exacerbates it. According to a study published in 2008, this prejudice, known as the Hawthorne effect, is mainly psychological. Even a placebo led to the complete elimination of ED.


If a doctor prescribes therapy that includes the combined use of Sildenafil and Metoprolol, he will definitely warn about the careful combined use of these two drugs.

Their cumulative interaction can lead to a sharp decrease in blood pressure and related adverse side effects.

At the same time, you should know the statement that treatment with Metoprolol can lead to erectile dysfunction is a myth debunked by clinical studies.

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